Cardiovascular PK/PD Simulator & Clinical Health Management Engine

💡 Educational Tool Notice: This application is designed solely as an interactive learning simulator. Please confirm all health and drug information with a qualified medical doctor before taking any action. Use of this application is at your own risk; we are not responsible for any outcomes, decisions, or damages that may result.

Cardio PK/PD & Health Engine

Name: Cardiovascular PK/PD Simulator & Health Engine
Creator: Ejiro Inije

PK/PD Simulator, Clinical Causes, Lifestyle & Dietary Management

Normal BP

About This Educational Engine

Dev: Ejiro Inije

Engineered as an interactive cardiovascular learning tool, this application simulates systemic pharmacokinetics, Hill-Emax pharmacodynamics, differential Windkessel hemodynamics, and comprehensive clinical lifestyle management. Designed by Ejiro Inije for academic exploration and clinical health education.

Baseline Blood Pressure (Linked Slider)

Baseline Profile: 140 / 90 mmHg (MAP: 106.7 mmHg)

Severe Hypotensive (50/32) Normal (120/80) Crisis (210/130)

7 Antihypertensive Classes (Real PK Parameters)

1. medication: Diuretic & Potassium Channel Regulator (Hydrochlorothiazide) Oral Tablet

Dose: 0 mg

DB00999 | t1/2: 10h, Vd: 210L, F: 70% | Toxic Ceiling: >1000 ng/mL

2. medication: Central Alpha-2 Agonist (Clonidine)

Dose: 0 mg

DB00575 | t1/2: 12h, Vd: 147L | Toxic Ceiling: >4.0 ng/mL

3. medication: Direct Vasodilator (Hydralazine)

Dose / Rate: 0 mg

DB01275 | t1/2: 4h, Vd: 112L | Toxic Ceiling: >2500 ng/mL

4. ACEi (Lisinopril) Oral Tablet

Dose: 0 mg

DB00722 | t1/2: 12h, Vd: 124L, F: 25% | Toxic Ceiling: >200 ng/mL

5. DHP CCB (Amlodipine) Oral Tablet

Dose: 0 mg

DB00381 | t1/2: 45h, Vd: 1400L, F: 64% | Toxic Ceiling: >30 ng/mL

6. Non-DHP CCB (Diltiazem)

Dose / Rate: 0 mg

DB00343 | t1/2: 4.5h, Vd: 305L | Toxic Ceiling: >300 ng/mL

7. Beta-Blocker (Metoprolol)

Dose / Rate: 0 mg

DB00999 | t1/2: 5h, Vd: 224L | Toxic Ceiling: >1000 ng/mL

Systolic (SBP) 140 mmHg

Diastolic (DBP) 90 mmHg

Calculated MAP 106.7 mmHg

Heart Rate 72 bpm

Dynamic Clinical & Patient Management Profile

Evaluated

🔍 Root Causes & Medical Indications

💊 Reasons For Medication

⚠️ Associated Symptoms & Risks

🏃 Lifestyle Interventions & Management

Control & Reversal Actions:

Prevention Strategy:

🥗 Meal & Dietary Recommendations

Therapeutic Meal Plan (DASH/Hypertension):

Long-Term Dietary Prevention:

RK4 Windkessel Waveform Integration

Compliance (C): 1.2 mL/mmHg Resistance (R): 1.0 mmHg·s/mL Inertance (L): 0.005 mmHg·s²/mL

🔒 Advanced Waveform & ODE Analytics Locked

High-fidelity 24-hour differential equation dynamics and full Windkessel parameter controls are restricted in this preview. Contact model expert Ejiro Inije for clear, descriptive training and full simulation access.

💬 Contact Model Expert on WhatsApp (+2348069907390)

24-Hour ODE Hemodynamic Dynamic Response

MAP = DBP + ⅓(SBP-DBP)