System Parameters
3.1 L
Physical blood plasma fluid volume (~3 to 5 L).
38 L
Total body water estimation minus Vc.
0.050
Unbound fraction in blood plasma (fu = 1 - Pb).
0.020
Unbound fraction inside extravascular tissue matrices.
12 L/hr
Capillary membrane diffusion transport capacity rate.
4.5 L/hr
Total volume of blood completely cleared per unit time.
500 mg
Initial mass injected directly into central blood plasma.
Steady-State Volume (Vss)
Oie-Tozer Model-- L
Vss = Vc + Vt × (fu / fut)
Tissue Partition (Kp)
Tissue Ratio--
Equilibrium ratio Kp = fu / fut
Distribution Half-Life (t1/2,α)
Fast Phase-- hrs
Rapid distribution decay rate constant α.
Terminal Half-Life (t1/2,β)
Slow Phase-- hrs
Terminal elimination decay rate constant β.
Biexponential Multi-Compartment Trajectories
Cc(t)
Cu(t)
At(t)